PE-22-28: Research Summary and How to Judge a Supplier
Spadin analogue studied in rodent models of depression via TREK-1 channel blockade. This profile sets out what is actually published, what a 10mg vial should cost, and the specific documentation to ask for before ordering PE-22-28 from any research supplier.
10mg
Typical vial
$35
Lowest tracked
$50
Median price
69
Vendors listing
What PE-22-28 is
PE-22-28 is a synthetic analogue of spadin, a peptide derived from the sortilin propeptide. Research attention centres on TREK-1 potassium channel blockade, a mechanism proposed as a faster-acting antidepressant pathway than monoamine reuptake inhibition, with rodent behavioural work reporting effects within days rather than weeks.
The literature is small, recent and almost entirely preclinical. There is no human efficacy data of any consequence, which is why our library grades the evidence as emerging and why suppliers listing it should be judged on analytical transparency rather than marketing narrative.
What the evidence base looks like
The published record is early: a coherent mechanism, a handful of encouraging studies, and very little independent replication at human scale.
Our library records roughly 14 relevant publications for PE-22-28 and grades the evidence as emerging. That grade describes the weight of research, not a judgement about safety or effect, and it is reviewed as new work is published.
Supplier quality: what to check on PE-22-28
Low market volume means fewer independent batches have ever been tested, so a recent, batch-matched certificate is more important here than on a mainstream product.
The practical checklist is the same on every product but weighted differently here: a batch-matched certificate of analysis, an identity method appropriate to this molecule rather than purity alone, clear peptide content per 10mg vial, and a supplier that will answer a technical question before taking payment.
Typical UK pricing
The lowest price we currently track for a 10mg vial is £34.90, against a market median nearer £50. Compare on price per milligram rather than per vial, because vial sizes across suppliers are rarely identical.
A listing well below the tracked low is worth investigating rather than celebrating. On this compound the cost of doing it properly is largely analytical, and that is the first thing an unusually cheap supplier stops paying for.
Frequently asked
Is PE-22-28 approved for human use?
No. Everything listed here is supplied for laboratory research use only, and nothing on this page is medical advice.
How much should PE-22-28 cost?
Tracked UK prices start around £34.90 for a 10mg vial, with the market median closer to £50.
What is the single most useful check on PE-22-28?
Low market volume means fewer independent batches have ever been tested, so a recent, batch-matched certificate is more important here than on a mainstream product.
Search focus for this profile
pe-22-28 — Tracked monthly searches, difficulty Monitored. Source: Semrush (UK database).
Supporting terms covered: pe-22-28 review, buy pe-22-28 uk, pe-22-28 price, best pe-22-28 supplier.
Everything below describes published research and market data. Nothing here is medical advice, and none of these compounds are sold or supplied by CheckALab.
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